ACTION AND MECHANISM

- [LAXATIVE]. Glycerol is a polyol derivative that acts as a laxative when administered rectally. Its effects are due to a dual mechanism of action:* Irritating effect on the rectal mucosa, without affecting the distal walls of the intestine. Local contraction of the rectal muscles quickly causes the expulsion of feces.* Osmotic effect. Glycerol has a high hygroscopic capacity, causing water to pass into the intestinal lumen. The increase in water, together with the lubricating properties of sorbitol, softens the stool and facilitates its elimination. The effects take between 15-30 minutes and one hour to appear.

SPECIAL WARNINGS

- The cause of constipation should be diagnosed before treatment, ruling out the possibility of gastrointestinal tract obstructions or appendicitis.

SENIORS

This medicine is not indicated for the elderly.

PATIENT ADVICE

- This medicine should not be used by patients with intestinal obstructions.
- If after 1 week of use, constipation does not improve, persists, or worsens, consult your doctor or pharmacist.
- Before starting treatment for constipation, lifestyle changes should be made. It is recommended to drink plenty of water daily (more than two liters), get an adequate intake of fiber, respond to the urge to defecate, and exercise.

CONTRAINDICATIONS

- Hypersensitivity to any component of the medication.- Situations in which gastrointestinal transit is difficult or impeded, such as [INTESTINAL OBSTRUCTION], [ILEUS] or [FECAL IMPACTION]. Due to the laxative effects of glycerol, the obstruction could be aggravated.- [ABDOMINAL PAIN] of unknown origin. Treatment with a laxative should not be started in patients suffering from abdominal pain until the cause has been identified, since the laxative could mask the symptoms of a more serious condition.- Pathologies in which it is dangerous to increase intestinal peristalsis, such as [APPENDICITIS] or [INTESTINAL PERFORATION]. The use of laxatives in these patients could aggravate the condition.

PREGNANCY

This medicine is not indicated for pregnant women.

PHARMACOKINETICS

- Absorption: Glycerol is barely absorbed when administered rectally, and is almost completely eliminated during defecation. However, oral absorption is high. Peak oral plasma concentrations are reached after 60-90 minutes.- Distribution: Absorbed glycerol is widely distributed throughout the body, accumulating in muscle fat.- Metabolism: It is extensively metabolized in the liver (around 80% of the absorbed amount).- Elimination: Glycerol is primarily eliminated by hepatic metabolism. Twenty percent of the absorbed glycerol appears unchanged in urine. The elimination half-life is 30-45 minutes.

INDICATIONS

- [CONSTIPATION]. Symptomatic local treatment of transient and occasional constipation.

INTERACTIONS

No drug interactions have been described.

LACTATION

This medicine is not indicated for women who are breastfeeding.

CHILDREN

Young children are often unable to clearly describe their symptoms, so a proper diagnosis should be made before using a laxative to avoid complications from existing conditions, such as appendicitis.

RULES FOR CORRECT ADMINISTRATION

Adult presentations are indicated for patients over 12 years of age, pediatric presentations for children 2-12 years of age, and infant presentations for children under 2 years of age.
After administration, bowel movements should be suppressed as long as possible to allow the glycerol to exert its effect. It is also recommended to keep the buttocks together for a while to prevent leakage.

POSOLOGY

* Children 2-12 years: 1 application (enema)/24 h.

PRECAUTIONS

- Symptoms of appendicitis, such as patients complaining of [NAUSEA], [VOMITING], or [ABDOMINAL CRAMPS]. In patients with these symptoms, it is recommended that appendicitis be ruled out, and if diagnosed, a laxative should not be used.

ADVERSE REACTIONS

Adverse reactions to glycerol are generally mild, transient, and local in nature. - Digestive. Occasionally, irritation, burning, or [ANAL ITCHING] may occur.

OVERDOSE

Symptoms: Use of this medication for long periods of time and at high doses may result in irritable bowel syndrome. Treatment: Treatment should be symptomatic. The laxative should be discontinued.

COMPOSITION

GLYCEROL: 1.8 MILLILITERS